Professor Chambers has a career-long interest in heart valve disease. His research is principally into improving the timing of surgery and developing new models of care-delivery. He set up one of the first specialist valve clinics in the world and has explored the use of hand-held echocardiography and scientist-led murmur clinics for the early detection of valve disease. He has chaired or been a member of working groups on standards defining specialist valve clinics, endocarditis services and heart valve centres as well as the imaging of aortic stenosis and prosthetic valves. He helped set up the British Society of Echocardiography and was president 2003-2005. He is a member of the ISO committee setting standards for testing novel prosthetic valves. He was a founder member and first president of the British Heart Valve Society. He teaches widely and has written books on a range of cardiac subjects including general echocardiography, valve disease, acute medicine, cardiac biomarkers and a patient information book on heart valve disease.